Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis

We studied immunohistochemical nuclear and/or cytoplasmic expression of oxidative stress markers 8-hydroxydeoxyguanosine and nitrotyrosine, as well as major antioxidative enzymes peroxiredoxins I–VI and thioredoxin in ovarian tumours

Marjo Pylväs; Ulla Puistola; Saila Kauppila; Ylermi Soini; Peeter Karihtala

2010

Scholarcy highlights

  • Oxidative stress and antioxidant enzymes have been widely investigated in various carcinomas
  • We studied immunohistochemical nuclear and/or cytoplasmic expression of oxidative stress markers 8-hydroxydeoxyguanosine and nitrotyrosine, as well as major antioxidative enzymes peroxiredoxins I–VI and thioredoxin in ovarian tumours
  • The levels of PRDX II, III, IV, V and VI were significantly higher in borderline than in benign tumours the difference between benign and borderline tumours was remarkable
  • Oxidative stress occurs already in benign ovarian tumours and the levels are comparable to borderline tumours
  • This difference could offer a potential tool for differential diagnosis between benign and borderline epithelial ovarian tumours

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