We studied immunohistochemical nuclear and/or cytoplasmic expression of oxidative stress markers 8-hydroxydeoxyguanosine and nitrotyrosine, as well as major antioxidative enzymes peroxiredoxins I–VI and thioredoxin in ovarian tumours
2010
Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis
Key concepts
Scholarcy highlights
- Oxidative stress and antioxidant enzymes have been widely investigated in various carcinomas
- We studied immunohistochemical nuclear and/or cytoplasmic expression of oxidative stress markers 8-hydroxydeoxyguanosine and nitrotyrosine, as well as major antioxidative enzymes peroxiredoxins I–VI and thioredoxin in ovarian tumours
- The levels of PRDX II, III, IV, V and VI were significantly higher in borderline than in benign tumours the difference between benign and borderline tumours was remarkable
- Oxidative stress occurs already in benign ovarian tumours and the levels are comparable to borderline tumours
- This difference could offer a potential tool for differential diagnosis between benign and borderline epithelial ovarian tumours
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