Detection and quantification of acidic drug residues in South African surface water using gas chromatography-mass spectrometry

A method was optimized for derivatization, separation, detection and quantification of salicylic acid, acetylsalicylic acid, nalidixic acid, ibuprofen, phenacetin, naproxen, ketoprofen, meclofenamic acid and diclofenac in surface water using gas chromatography-mass spectrometry

Bhekumuzi P. Gumbi; Brenda Moodley; Grace Birungi; Patrick G. Ndungu

2016

Scholarcy highlights

  • A method was optimized for derivatization, separation, detection and quantification of salicylic acid, acetylsalicylic acid, nalidixic acid, ibuprofen, phenacetin, naproxen, ketoprofen, meclofenamic acid and diclofenac in surface water using gas chromatography-mass spectrometry
  • For most of the acidic drugs, recovery was in the range 60–110% and the percent standard deviation was below 15% for the entire method, with limits of detection ranging from 0.041 to 1.614 μg L−1
  • The developed method was applied in the analysis of acidic drugs in Umgeni River system, KwaZulu-Natal South Africa
  • All of the selected acidic drugs were detected and quantified, their concentration in Umgeni River system ranged from 0.0200 to 68.14 μg L−1

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