Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis in zebrafish larvae

Microcystin–leucine–arginine is the most toxic and the most commonly encountered variant of microcystins in aquatic environment, and it has the potential for disrupting thyroid hormone homeostasis, but the molecular mechanisms underlying this process have not yet been clarified

Wei Yan; Youxiang Zhou; Jie Yang; Shuqian Li; Dingjin Hu; Jianghua Wang; Jun Chen; Guangyu Li

2012

Scholarcy highlights

  • Microcystin–leucine–arginine is the most toxic and the most commonly encountered variant of microcystins in aquatic environment, and it has the potential for disrupting thyroid hormone homeostasis, but the molecular mechanisms underlying this process have not yet been clarified
  • We observed body growth retardation associated with decreased levels of thyroid hormones in zebrafish larvae, highlighting the interferences of MCLR with the growth of fish larvae
  • To further our understanding of mechanisms of MCLR-induced endocrine toxicity, quantitative real-time PCR analysis was performed on hypothalamic–pituitary–thyroid axis related genes of developing zebrafish embryos exposed to 100, 300 and 500 μg L−1 MCLR until 96 h post-fertilization
  • The gene expression levels of corticotropin-releasing factor, thyroid-stimulating hormone, NIS and TG were significantly induced after exposure to 500 μg L−1 MCLR
  • The above results indicated that MCLR could alter gene expression in the HPT axis which might subsequently contribute to MCLR-induced thyroid disruption

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