Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae

The results showed that crh, slc5a5, tg and tshβ mRNA levels were significantly up-regulated in the larvae, but the gene expression of trα and trβ was down-regulated in a concentration-dependent manner

Zhi-Hua Li; Lu Chen; Yan-Hua Wu; Ping Li; Yun-Feng Li; Zhao-Hui Ni

2014

Scholarcy highlights

  • Cadmium is a heavy metal abundant in the environment that can induce endocrine disorder and toxicity in aquatic organisms at low levels
  • The thyroid hormone levels and the expression profiles of genes related to hypothalamic– pituitary–thyroid axis, including corticotropin-releasing hormone, thyroid stimulating hormone beta, solute carrier family 5 member 5, thyroglobulin, thyroid hormone receptor alpha and thyroid hormone receptor beta, were determined in whole body of Chinese rare minnow larvae after exposure to different levels of Cd2 + for 4 days
  • The 96-h lethal concentration of Cd2 + on rare minnow larvae was determined as 2.59 mg/L
  • The results showed that crh, slc5a5, tg and tshβ mRNA levels were significantly up-regulated in the larvae, but the gene expression of trα and trβ was down-regulated in a concentration-dependent manner
  • The THs levels decreased in the whole-body of fish, especially the thyroxine level
  • The above results indicated that Cd2 + could alter gene expression in the HPT axis that might subsequently contribute to thyroid disruption
  • The above results indicated that Cd2 + could alter gene expression in the hypothalamic– pituitary–thyroid axis that might subsequently contribute to thyroid disruption

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