Characterization of the peripheral thyroid system of gilthead seabream acclimated to different ambient salinities

Our findings reveal that fT3 levels partially modulate pituitary expression of tshb, its fine regulation is dependent on the total amount of T3 and/or T4 in plasma

I. Ruiz-Jarabo; P.H.M. Klaren; B. Louro; J.A. Martos-Sitcha; P.I.S. Pinto; L. Vargas-Chacoff; G. Flik; G. Martínez-Rodríguez; D.M. Power; J.M. Mancera; F.J. Arjona

2016

Scholarcy highlights

  • Thyroid hormones are truly pleiotropic in fish, affecting metabolism, reproduction, growth and osmoregulation, relevant physiological processes for aquaculture
  • No mortality was recorded during the experimental period
  • The full-length sequence of S. aurata tshb consisted of 870 bp and had an open reading frame of 438 nucleotides that encoded a 146 aa protein
  • Multiple sequence alignment of Tshb from seabream and a wide selection of vertebrates revealed they shared from 39% aa sequence conservation with mammals and reptiles up to 92% aa sequence conservation with Perciformes
  • We provide some correlations between plasma fT4 concentrations and expression of dio2 in both gills and kidney, indicating an enhancement in peripheral Outer ring deiodination activity when circulating T4 levels increase
  • Environmental salinity modulated ORD activity in osmoregulatory tissues such as the gills and kidney supporting the idea that the thyroid system is involved in osmoregulation in fish

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