In vitro permeability enhancement of curcumin across Caco-2 cells monolayers using electrospun xanthan-chitosan nanofibers

ED In the present study, we report the formation of electrospun xanthan-chitosan nanofibers as an T encapsulation and delivery system of curcumin

Adele Faralli

2018

Scholarcy highlights

  • S Curcumin is a polyphenolic compound obtained from the dietary spice turmeric found in the U Asian plant Curcuma longa
  • Electrospinning of Xanthan - Chitosan nanofibers Xanthan-Chitosan nanofibers were obtained by electrospinning mixtures of X at the concentration of 0.75% w/v with 3% w/v Ch dissolved in formic acid
  • The average diameter of electrospun xanthan-chitosan nanofibers slightly IP increased to 900 ± 440 nm with the addition of 2% w/v curcumin
  • C the proposed curcumin delivery system showed the highest amount of curcumin A permeating the epithelial cell monolayers with a Papp, AB = 1.49x10-5 cm/s and a Papp, BA = 7.00x10-6 cm/s, and a 2-fold permeability enhancement was measured when Xanthan-Chitosan nanofibers were added to a free curcumin solution in the donor side compared to free curcumin without fibers
  • After 24 h of incubation, the exposure of Caco-2 cell monolayers R to X-Ch and X-Ch-Cu nanofibers resulted in a cell viability of >90% and ~80%, respectively
  • A C 3.4-fold increase of curcumin permeability was observed in the presence of X-Ch fibers, in S comparison with free-curcumin
  • In vivo experiments are required to fully demonstrate the efficiency

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