PCL/chitosan/Zn-doped nHA electrospun nanocomposite scaffold promotes adipose derived stem cells adhesion and proliferation

Chitosan, and poly(ɛ-caprolactone), widely used as biomaterials with desirable properties for tissue engineering applications, were both blended with zinc-doped hydroxyapatite nanoparticles(nZnHA) and electrospun into nanofibrous scaffolds using formic acid/acetic acid

Fereshteh Mohammad Ghorbani; Babak Kaffashi; Parvin Shokrollahi; Ehsan Seyedjafari; Abdolreza Ardeshirylajimi

2014

Scholarcy highlights

  • Chitosan, and poly(ɛ-caprolactone), widely used as biomaterials with desirable properties for tissue engineering applications, were both blended with zinc-doped hydroxyapatite nanoparticles(nZnHA) and electrospun into nanofibrous scaffolds using formic acid/acetic acid
  • The rationale behind this study was to demonstrate that presence of small quantities of Zn2+ ions doped in HA nanoparticles can improve biocompatibility of PCL/Ch blends
  • SEM observation revealed that average fiber diameter was increased from about 136 nm for a PCL/Ch blend, to around 210 nm for PCL/Ch/nZnHA nanocomposite
  • PCL/Ch/nZnHA scaffolds offered higher elastic modulus and tensile strength than the corresponding PCL/Ch scaffolds

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