Peroxiredoxins, a novel target in cancer radiotherapy

Reactive oxygen species are toxic at high levels in the mammalian cells

Bo Zhang; Yan Wang; Yongping Su

2009

Scholarcy highlights

  • Reactive oxygen species are toxic at high levels in the mammalian cells
  • Mammalian cells have developed many enzymatic and nonenzymatic antioxidative systems in various cellular compartments to maintain an appropriate level of ROS and regulate their action
  • We discussed the regulation of Prxs expression in cancer cell and its relationship with ionizing radiation
  • As Prxs could be induced by radiation and its expression status could determine the radiosensitivity of cancer cells, Prxs might be a potential target for radiotherapy in cancer

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