Tissue modulus calculated from beam theory is biased by bone size and geometry: Implications for the use of three-point bending tests to determine bone tissue modulus

We found that by using beam theory, tissue modulus was underestimated for all femora

G. Harry van Lenthe

2008

Key concepts

Scholarcy highlights

  • We measured the three-dimensional structure of male and female B6 and C3H femora by means of micro-computed tomography
  • Our aim was to assess the accuracy of beam theory, which we tested for two commonly used inbred strains of mice, C57BL/6 and C3H/He
  • Tissue modulus was calculated from beam theory using micro-FE results
  • An additional set of fresh-frozen femora was biomechanically tested and subjected to the same micro-FE analyses. These combined experimental–computational analyses enabled an unbiased assessment of specimen-specific tissue modulus
  • We found that by using beam theory, tissue modulus was underestimated for all femora
  • We conclude that tissue moduli in murine femora are strongly underestimated when calculated from beam theory
  • We suggest a re-evaluation of the tissue properties obtained from three-point bending tests, especially in mouse genetics

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