Synthetic agonist of HTL/KAI2 shows potent stimulating activity for Arabidopsis seed germination

We demonstrated that designed chemicals with a phenoxyfuranone scaffold potently stimulated seed germination via HTL/KAI2 in Arabidopsis

Kosuke Fukui; Kazushi Arai; Hiroyuki Kasahara; Tadao Asami; Ken-ichiro Hayashi

2019

Scholarcy highlights

  • HTL/KAI2, a member of the α/β-fold hydrolase superfamily, is known to be a receptor-like protein of lactone compounds and that triggers seed germination of Arabidopsis
  • To understand the mechanism underlying seed germination involved in HTL/KAI2 signaling, it is necessary to identify the endogenous ligand of HTL/KAI2
  • Because exogenous agonistic chemicals can only be purchased in small amounts at high prices, the limited supply of those chemicals has hampered any large-scale experiments, such as mutant screening
  • Synthesized and scalable artificial agonist would remove the limitation of the chemical supply and contribute to the identification of the endogenous ligand of HTL/KAI2 and/or the biosynthetic mutants
  • We demonstrated that designed chemicals with a phenoxyfuranone scaffold potently stimulated seed germination via HTL/KAI2 in Arabidopsis
  • We provide a new promising synthetic agonist of HTL/KAI2

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