CdZnTeS quantum dots based electrochemiluminescent image immunoanalysis

In this work, quaternary CdZnTeS quantum dots with a strong electrochemiluminescence were synthesized as ECL signal labels

Xiu-Li Liang; Ning Bao; Xiliang Luo; Shou-Nian Ding

2018

Scholarcy highlights

  • In this work, quaternary CdZnTeS quantum dots with a strong electrochemiluminescence were synthesized as ECL signal labels
  • The detection of AFP and cancer antigen 125 were accomplished with direct ECL image analysis
  • The QDs-based ECL image immunoanalysis possessed good linearity from 0.5 ng/mL to 20 ng/mL for AFP and from 20 U/mL to 500 U/mL for CA125 with the detection limit of 0.1 ng/mL and 6 U/mL, respectively, and the lower detection limit obtained by photomultiplier tube were 0.1 fg/mL for AFP and 0.03 mU/mL for CA125 with the wide dynamic range from 0.5 fg/mL to 20 ng/mL and from 0.1 mU/mL to 500 U/mL, respectively
  • The ECL immunoanalysis was evaluated with commercial enzyme-linked immunosorbent assay in human serum samples
  • The good results indicated that CdZnTeS QDs-based ECL biosensor has great potential for fast biomedical screening and multi-assays in clinical diagnosis

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