Label-free detection of ATP release from living astrocytes with high temporal resolution using carbon nanotube network

Owing to its unique combination of electrical, physiochemical, and one-dimension structural properties, single-walled carbon nanotube has recently emerged as a novel nanoelectronic biosensor for biomolecular detection with extraordinary sensitivity and simple detection scheme

Yinxi Huang; Herry Gunadi Sudibya; Dongliang Fu; Renhao Xue; Xiaochen Dong; Lain-Jong Li; Peng Chen

2008

Scholarcy highlights

  • Owing to its unique combination of electrical, physiochemical, and one-dimension structural properties, single-walled carbon nanotube has recently emerged as a novel nanoelectronic biosensor for biomolecular detection with extraordinary sensitivity and simple detection scheme
  • Dynamic detection of biomolecule release from living cells which may occur in millisecond timescale has yet to be demonstrated
  • The secreted adenosine triphosphate molecules diffuse into the narrow interface gap between the SWNT-net and the astrocyte, and interact with the nanotubes
  • Charged ATP molecules electrostatically modulate the SWNT conductance leading to measurable current response
  • This technique provides a novel platform to study adenosine triphosphate release and signaling which play important roles in astrocyte–neuron crosstalk and other essential cellular functions

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