Effects of standard ethanolic extract from Erythrina velutina in acute cerebral ischemia in mice

The objective of this study was to verify a possible neuroprotective effect of the ethanolic extract of Erythrina velutina

Francisca Taciana Sousa Rodrigues; Caren Nádia Soares de Sousa; Naiara Coelho Ximenes; Anália Barbosa Almeida; Lucas Moraes Cabral; Cláudio Felipe Vasconcelos Patrocínio; Aline Holanda Silva; Luzia Kalyne Almeida Moreira Leal; José Eduardo Ribeiro Honório Júnior; Danielle Macedo; Silvânia Maria Mendes Vasconcelos

2017

Scholarcy highlights

  • The objective of this study was to verify a possible neuroprotective effect of the ethanolic extract of Erythrina velutina
  • Amino acid dosage showed an increase in excitatory amino acid concentrations in the prefrontal cortex of the ischemic animals and this effect was reversed by the treatment with EEEV400/24H
  • Regarding the inhibitory amino acids, ischemia caused an increase of taurine in the PFC while treatment with MEM10/24H or EEEV400/24H reversed this effect
  • In the ST, ischemia was able to cause an increase in excitatory amino acids that was reversed more efficiently by the treatments with MEM10/24H and EEEV200
  • In view of these findings, EEEV presents a neuroprotective effect possibly due to its action on amino acid concentrations, and is a potential therapeutic tool in reducing the damage caused by ischemia

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