Paclitaxel-releasing mesenchymal stromal cells inhibit in vitro proliferation of human mesothelioma cells

Malignant pleural mesothelioma is a rare fatal asbestos-related malignancy originating in the mesothelial cells of the pleura

Francesco Petrella

2017

Scholarcy highlights

  • Malignant pleural mesothelioma is a rare fatal asbestos-related malignancy originating in the mesothelial cells of the pleura
  • A platinum-based doublet containing a third-generation antifolate is the front-line standard of care whilst there are no approved second-line treatments for MPM which remains a disease setting to test the efficacy of new therapeutic agents
  • Further studies and in vivo testing are required to confirm our preliminary in vitro results as a potential new mesothelioma therapy based on cell drug delivery

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