Nitrogen-doped graphene quantum dots (N-GQDs) perturb redox-sensitive system via the selective inhibition of antioxidant enzyme activities in zebrafish

We found that nitrogen-doped Graphene quantum dots can strongly disturb redox-sensitive system via the selective inhibition of endogenous antioxidant enzyme activities in zebrafish

Shun Deng; Ailing Fu; Muhammad Junaid; Yan Wang; Qian Yin; Chen Fu; Li Liu; Dong-Sheng Su; Wan-Ping Bian; De-Sheng Pei

2019

Scholarcy highlights

  • Graphene quantum dots are structurally composed of single-layer or multiple layers of graphene, for sizes typically below 20 nm, which are considered as quasi-zero-dimensional nanomaterials
  • We found that nitrogen-doped GQDs activated the cytochrome P450 monooxygenase and the associated aryl-hydrocarbon receptor repressors in zebrafish embryos
  • Our results provide preliminary evidence of the potential adverse effects of N-GQDs in vivo system
  • Derived from graphene oxide, N-GQDs do not inherit most toxicity mechanisms from its parent and develop specific biological effects using in vivo system
  • The present study examined the toxic effects of the exposure to different concentrations of the ionic liquid 1-octyl-3-methylimidazolium hexafluorophosphate for a 28-day period in zebrafish
  • For the top-down method, the quantum yields are usually lower than 1%
  • Reduced glutathione levels in the zebrafish brain exposed to high or low doses of aphantoxins decreased by 44.88% and 41.33%, respectively, after 1–12 h compared with the controls, suggesting that GSH participated in detoxification to reactive oxygen species and MDA
  • We here reported the fluorescence enhancement effects and bio-accumulative effects of N-Graphene quantum dots in zebrafish models, and revealed that nitrogen-doped GQDs could perturb the endogenous antioxidant enzyme system via transcriptional or post-transcriptional repression

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