Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

We review recent research on the synthesis, characterizations and biomedical applications of gelatin methacryloyl, which is frequently referred as gelatin methacrylate, methacrylated gelatin, methacrylamide modified gelatin, or gelatin methacrylamide in literature by different authors

Kan Yue

2015

Scholarcy highlights

  • Hydrogels are crosslinked network of hydrophilic polymers that can swell in water to capture many times their original mass
  • Hydrogels based on naturally occurring biopolymers have many advantages over synthetic polymers, such as excellent biocompatibility, low immunoresponse, and possible bioactive motifs encoded in their chemical structures
  • We review hybrid hydrogels based on Gelatin methacryloyl and other constituents including carbon nanotubes, graphene oxide, inorganic nanoparticles, other biopolymers, and synthetic polymers. 4.1
  • We have reviewed several important aspects of GelMA-based hydrogel systems for biomedical applications
  • GelMA is developed from a natural polymer gelatin via one-step chemical modification
  • Fibroblasts growing on 10%GelMA-10%polyethylene glycol covered more than 10% of the area of culture within the same time period
  • Many physical parameters of GelMA hydrogels, such as mechanical properties, pore sizes, degradation rates, and swell ratio can be readily tailored by changing the degree of methacryloyl substitution, concentration of the GelMA prepolymer, initiator concentration, and UV exposure time
  • The resulting Gelatin methacryloyl hydrogels retain the excellent biocompatibility and bioactivity of gelatin, such as promoting adhesion, spreading, and proliferation of various cell lines, due to the existence of cell adhesive RGD motifs and

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