pH-Responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy

To overcome stability and organ distribution defects of liposomes, we have recently shown that a sophisticated tumor-extracellular matrix switched-on targeting liposome composed of dipalmitoylphosphatidylcholine, methoxy-poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide-co-histidine)-cholesterol copolymers and biotin-polyethylene glycol-biotin crosslinkers

Yi-Ting Chiang

2014

Scholarcy highlights

  • Liposome, an important drug carrier, has low toxicity and biocompatibility and is widely used in pharmaceutical formulations,,
  • Liposomes can accumulate in tumors by the enhanced permeability and retention effect, many studies have reported that accumulation of liposomes in the liver or spleen is preferential to that in a tumor, causing macrophage toxicity,,,
  • To overcome stability and organ distribution defects of liposomes, we have recently shown that a sophisticated tumor-extracellular matrix switched-on targeting liposome composed of dipalmitoylphosphatidylcholine, methoxy-poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide-co-histidine)-cholesterol copolymers and biotin-polyethylene glycol-biotin crosslinkers
  • We summarized recent NPs-based strategies aiming at regulating tumor microenvironment in different ways, including anti-angiogenesis, extracellular matrix remodeling, tumor-associated fibroblasts treatment and tumor-associated macrophages treatment, along with the miRNAs-loaded NPs for TME regulation
  • A targeted and NIR-triggered drug delivery system is developed based on a NIR dye, indocyanine green, and anticancer drug, doxorubicin hydrochloride-loaded thermo-responsive block copolymer capsule, in which the drug release can be controlled via NIR irradiation and folic acid molecule endows the drug carrier with the ability of targeted receptor-mediated endocytosis
  • Results demonstrate that the synergy of target-specific association, temperature-triggered drug release, and imaging is important for efficient tumor chemotherapy

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