Endocrine disruptors and thyroid hormone physiology

This study demonstrated that prenatal exposure was about two- to ed threefold lower than in Dusseldorf, and that prenatal polychlorinated biphenyls exposure did not impair neurodevelopment in the children in the Duisburg cohort

Mary-Line Jugan; Yves Levi; Jean-Paul Blondeau

2009

Scholarcy highlights

  • The term endocrine disruptor is used to describe substances that can potentially interfere with the endocrine system
  • This study demonstrated that prenatal exposure was about two- to ed threefold lower than in Dusseldorf, and that prenatal polychlorinated biphenyls exposure did not impair neurodevelopment in the children in the Duisburg cohort
  • We reported in the previous section that thyroid-disrupting chemicals are usually identified by their potential to affect circulating thyroid hormone levels
  • Thyroid hormones are strongly involved in vertebrate brain development, from early embryogenesis to subsequent prenatal and perinatal development in mammals
  • Several epidemiological data have indicated that pollutant exposure might lead to impaired developmental processes, which could be associated with the homeostasis and action of TH
  • Maternal dioxin-like PCBs were significantly associated with lower scores on both the psychomotor and mental development indices
  • The mechanisms of action of TDCs are complex and, TRindependent mechanisms have been elucidated, there is a lack of data about TH receptors

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