SALL4 suppresses reactive oxygen species in pancreatic ductal adenocarcinoma phenotype via FoxM1/Prx III axis

We have found the role Spalt like protein 4 to Pancreatic ductal adenocarcinoma proliferation, mobility and its regulation to mitochondrial reactive oxygen species via FoxM1/Prx III axis

Do Luong Huynh; Jiao Jiao Zhang; Nisansala Chandimali; Mrinmoy Ghosh; Meeta Gera; Nameun Kim; Yang Ho Park; Taeho Kwon; Dong Kee Jeong

2018

Scholarcy highlights

  • Pancreatic ductal adenocarcinoma is a major malignant phenotype in pancreatic cancer, which is one of the most death causes by cancer in the world
  • PDAC developed from pancreatic intra-epithelial neoplasms and poorly diagnosed at early stages
  • Beside of high drug resistance, metastasis is the great concern during pancreatic cancer treatment
  • We have found the role Spalt like protein 4 to PDAC proliferation, mobility and its regulation to mitochondrial reactive oxygen species via FoxM1/Prx III axis
  • SALL4 might be a promising marker for PDAC treatment and targeting SALL4 would benefit anti-proliferative and anti-metastasis therapies
  • Spalt like protein 4 might be a promising marker for Pancreatic ductal adenocarcinoma treatment and targeting SALL4 would benefit anti-proliferative and anti-metastasis therapies

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