c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1α

We investigated the role of c-Myc in tumor angiogenesis

Cheng Chen; Shaoxin Cai; Guihua Wang; Xiaonian Cao; Xi Yang; Xuelai Luo; Yongdong Feng; Junbo Hu

2012

Scholarcy highlights

  • Angiogenesis plays a pivotal role in tumor growth
  • We investigated the role of c-Myc in tumor angiogenesis
  • We found that the overexpression of c-Myc in colon cancer cells could promote the expression of HIF-1α and that of vascular endothelial growth factor
  • This research provides the theoretical basis for clinical trials of new therapeutic targets of c-Myc and HIF-1α in colon cancer cells
  • ► We investigated the role of c-Myc in tumor angiogenesis. ► c-Myc regulated HIF-1α at the post-transcriptional level. ► We firstly found c-Myc-dependent regulation of HIF-1α. ► c-Myc enhanced angiogenesis through the HIF-1α/VEGF pathway

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