The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma

We have reviewed the involvement of erionite, simian virus 40, as well as, the role of several genes, LATS2, salvador gene, the pathways, and their respective roles in the development of MM

Leonardo Vinícius Monteiro de Assis

2014

Scholarcy highlights

  • Malignant Mesothelioma is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage
  • This study has shown that lower amounts of asbestos may cause MM in animals infected by simian virus 40, and similar conclusions have been found by another study
  • The risk factors are of great importance in the development of this cancer, such as erionite, asbestos and SV40; more studies are needed in order to better comprehend how these players influence the development of MM, as well as the levels of exposure that are dangerous for the population
  • The majority of the population is not exposed to such risk factors, something that extensively reduces the likelihood of developing MM
  • This fact in association with an ever-increasing knowledge on the biochemical and genomic pathways to drive the tumorigenesis of MM, gives us valuable clues, which would result in the production of more specific molecules and drugs, which would be used to fight against the process of malignant transformation, establishment and metastasis
  • Our work shows that several genes and pathways are involved in the development of MM; more studies are needed in order to better understand, prevent, diagnose, and treat this very aggressive cancer

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