Vitamin D and juvenile systemic lupus erythematosus: Lights, shadows and still unresolved issues

Systemic lupus erythematosus and juvenile SLE are autoimmune disorders naturally associated with several genetic, environmental, hormonal, and immunological contributing factors

Stefano Stagi

2018

Scholarcy highlights

  • Systemic lupus erythematosus and juvenile SLE are autoimmune disorders naturally associated with several genetic, environmental, hormonal, and immunological contributing factors
  • It has been assumed that vitamin D deficiency may have a role in the immune activation of patients with SLE and play an active part in many comorbidities and even complications
  • A host of clinical studies suggested that vitamin D exerts inhibitory effects on many immunological abnormalities associated with SLE, in children and adolescents, while different reports have hypothesized that vitamin D may be associated with accelerated cardiovascular disease in SLE
  • This review updates and summarizes the information related to the immunoregulatory effects of vitamin D and its importance in juvenile SLE, discusses the innumerable correlations between vitamin D and disease activity, including clinical expression and gene polymorphisms of vitamin D receptor as well as the recommendations for vitamin D supplementation in these patients
  • Despite the excitement raised by many data obtained about vitamin D and its influence on several aspects of the disease, further well-designed perspective trials are required to define the exact role that vitamin D may have in the management of both SLE and jSLE

Need more features? Save interactive summary cards to your Scholarcy Library.