Body Mass Index and Total Psoas Area Affect Outcomes in Patients Undergoing Pneumonectomy for Cancer

Pathophysiologic characteristics of body composition in this condition, we evaluated the psoas area, perirenal fat, and abdominal subcutaneous fat, together with clinical, laboratory, and pathologic determinations to study respective interrelations and impact on short- and long-term outcomes

Remi Hervochon

2016

Scholarcy highlights

  • Hypothesizing that morphometric measurements are reliable markers of fitness in patients with lung cancer requiring aggressive surgical intervention, the purpose of this study was to assess their impact on postoperative outcome and long-term survival in patients with non-small cell lung cancer requiring pneumonectomy
  • Weight, and body mass index, as well as usual clinical, laboratory, and pathologic data were retrospectively retrieved from files of 161 consecutive patients treated by pneumonectomy for NSCLC, whose preoperative computed tomographic scans were available in the Picture Archive and Communication System of the hospital
  • BMI and total psoas area were strongly and directly correlated, whereas BMI was inversely related to C-reactive protein levels
  • Long-term outcome was negatively affected by a nonsquamous cell histologic type, pathologic stage IIIB–IV, CRP levels greater than 20 mg/L, BMI less than or equal to 25 kg/m2, and total psoas area less than or equal to the 33rd percentile
  • We could suggest that host-related factors should be integrated into the prognostic evaluation of patients with NSCLC requiring pneumonectomy; in particular we propose that TPA could be integrated into the radiology reports of patients with lung cancer requiring operative treatment
  • It is recognized that stage classification does not completely

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