Meta-Analysis of Survival After Pleurectomy Decortication Versus Extrapleural Pneumonectomy in Mesothelioma

This comprehensive meta-analysis was conducted to answer the question as to which procedure, pleurectomy decortication or extrapleural pneumonectomy is more beneficial to malignant pleural mesothelioma patients’ outcome

Emanuela Taioli

2014

Scholarcy highlights

  • This comprehensive meta-analysis was conducted to answer the question as to which procedure, pleurectomy decortication or extrapleural pneumonectomy is more beneficial to malignant pleural mesothelioma patients’ outcome
  • There were 24 distinct data sets, for a total of 1,512 patients treated with P/D, and 1,391 treated with EPP
  • There was a significantly higher proportion of short-term deaths in the EPP group versus the P/D group
  • The reanalysis of the large number of studies comparing P/D to EPP suggests that P/D is associated with a 2 ½-fold lower short-term mortality than EPP
  • Surgery plays an important role in Malignant pleural mesothelioma management, and is carried out according to 2 main procedures; radical pleurectomy decortication and extrapleural pneumonectomy
  • ] overlapped and relied on the same source populations and were considered as 2 distinct data sets, bringing the number of distinct data sets to 24, for a total of 1,512 patients treated with P/D, and 1,391 treated with EPP
  • The success of the 3 available options in Malignant pleural mesothelioma treatment have been controversial

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