Thyroid endocrine disruption in zebrafish larvae following exposure to hexaconazole and tebuconazole

The results showed that thyroxine levels were significantly decreased, while triiodothyronine concentrations were significantly increased after exposure to HEX and TEB, indicating thyroid endocrine disruption

Liang Yu; Mengli Chen; Yihua Liu; Wenjun Gui; Guonian Zhu

2013

Scholarcy highlights

  • Zebrafish embryos were exposed to hexaconazole and tebuconazole respectively
  • The whole body thyroxine levels were decreased while triiodothyronine were increased
  • Hexaconazole and tebuconazole exposure might result in thyroid endocrine toxicity
  • The widely used triazole fungicides have the potential to disrupt endocrine system, but little is known of such effects or underlying mechanisms of hexaconazole and tebuconazole in fish
  • The results showed that thyroxine levels were significantly decreased, while triiodothyronine concentrations were significantly increased after exposure to HEX and TEB, indicating thyroid endocrine disruption
  • The overall results indicated that exposure to HEX and TEB could alter thyroid hormone levels as well as gene transcription in the HPT axis in zebrafish larvae

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