Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic–pituitary–thyroid axis

These results suggested that the HPT axis in 144-hpf zebrafish larvae was responsive to chemical exposure and could be used to evaluate the effects of chemicals on the thyroid endocrine system

Qiangwei Wang; Kang Liang; Jingfu Liu; Lihua Yang; Yongyong Guo; Chunsheng Liu; Bingsheng Zhou

2012

Scholarcy highlights

  • Tris(1,3-dichloro-2-propyl) phosphate has been frequently detected in the environment and in various biota, including fish, and has been implicated in disruption of the thyroid endocrine system
  • Developmental endpoints, and whole-body concentrations of thyroid hormones and transcriptional profiles of genes involved in the hypothalamic–pituitary–thyroid axis were examined
  • Treatment with the positive control chemical 3,3′,5-triiodo-l-thyronine significantly decreased whole-body thyroxin concentrations, increased whole-body T3 concentrations, and upregulated mRNA expression involved in the HPT axis as a compensatory mechanism
  • These results suggested that the HPT axis in 144-hpf zebrafish larvae was responsive to chemical exposure and could be used to evaluate the effects of chemicals on the thyroid endocrine system
  • Treatment with TDCPP significantly increased transcription of genes involved in thyroid hormone synthesis and thyroid development as a compensatory mechanism for decreased T4 concentrations. These results suggest that TDCPP alters the transcription of genes involved in the HPT axis and changes whole-body concentrations of thyroid hormones in zebrafish embryos/larvae, causing an endocrine disruption of the thyroid system

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