Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae

Gene transcription in the hypothalamic–pituitary–thyroid axis was further examined, and the results showed that the genes encoding corticotrophin-releasing hormone and thyroid-stimulating hormone were transcriptionally significantly up-regulated

Qi Chen; Liqin Yu; Lihua Yang; Bingsheng Zhou

2012

Scholarcy highlights

  • Polybrominated diphenyl ethers have the potential to disturb the thyroid endocrine system, but little is known of such effects or underlying mechanisms of BDE-209 in fish
  • Bioconcentration and metabolism of BDE-209 were investigated in zebrafish embryos exposed at concentrations of 0, 0.08, 0.38 and 1.92 mg/L in water until 14 days post-fertilization
  • Gene transcription in the hypothalamic–pituitary–thyroid axis was further examined, and the results showed that the genes encoding corticotrophin-releasing hormone and thyroid-stimulating hormone were transcriptionally significantly up-regulated
  • Protein synthesis of TG was significantly up-regulated, while that of TTR was significantly reduced. These results suggest that the hypothalamic–pituitary–thyroid axis can be evaluated to determine thyroid endocrine disruption by BDE-209 in developing zebrafish larvae
  • ► Thyroid endocrine disruption was investigated in zebrafish larvae following exposure of embryos to BDE-209. ► Both T4 and T3 levels were changed by BDE-209 exposure. ► Modulation of gene transcription in the hypothalamic–pituitary–thyroid axis was examined. ► Bioaccumulation and metabolism of BDE-209 were evident. ► HPT axis can be used for testing endocrine disruption of THs by BDE-209, a higher PBDE congener
  • ► HPT axis can be used for testing endocrine disruption of THs by BDE-209, a higher Polybrominated diphenyl ethers congener

Need more features? Save interactive summary cards to your Scholarcy Library.