Thyroid dysfunction in sea bass (Dicentrarchus labrax): Underlying mechanisms and effects of polychlorinated biphenyls on thyroid hormone physiology and metabolism

The current study examines the effect of subchronic exposure to a mixture of Aroclor standards on thyroid hormone physiology and metabolism in juvenile sea bass

Joseph G. Schnitzler; Niko Celis; Peter H.M. Klaren; Ronny Blust; Alin C. Dirtu; Adrian Covaci; Krishna Das

2011

Scholarcy highlights

  • In a recent field study we have established correlations between exposure to organochlorine contaminants and thyroid function in wild sea bass from European coasts
  • Weight and condition factor were found between polychlorinated biphenyls exposed and control sea bass and no other external sign of adverse effects of PCB exposure could be observed
  • The initial average concentrations of PCBs measured in sea bass muscle used in accumulation experiments were close to or lower than the method LOQ
  • Our study demonstrates that subchronic exposure to a mixture of PCBs affects thyroid hormone physiology in juvenile sea bass
  • Ultrastructural histological investigations showed a potential inhibition of thyroglobulin proteolysis and thyroid hormone release in the thyroids of high exposed fish
  • The presented mechanisms are part of the extensive autoregulatory feedback control at both central and peripheral levels, and the induced changes in thyroid hormone dynamics keep the levels in an acceptable range
  • We observed degenerative histological changes in the thyroid tissue that might have caused the hypothyroidism in these fish

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