Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis of zebrafish larvae

Polybrominated diphenyl ethers have the potential to disrupt thyroid hormone homeostasis, but the molecular mechanisms underlying this process have not yet been clarified

Liqin Yu; Jun Deng; Xiongjie Shi; Chunsheng Liu; Ke Yu; Bingsheng Zhou

2009

Scholarcy highlights

  • Polybrominated diphenyl ethers have the potential to disrupt thyroid hormone homeostasis, but the molecular mechanisms underlying this process have not yet been clarified
  • The transcription of genes involved in the synthesis of TH proteins, sodium/iodide symporter, and thyroglobulin and the transcription of marker genes associated with early thyroid development were significantly upregulated upon DE-71 exposure
  • The results of our study confirmed the reliability of the zebrafish larvae as models for assessment of the developmental toxicity of PBDEs and transcription of genes of the HPT axis can evaluate the potential mechanisms of thyroid disruption

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