Changes of thyroid hormone levels and related gene expression in Chinese rare minnow (Gobiocypris rarus) during 3-amino-1,2,4-triazole exposure and recovery

These results indicated that amitrole exposure could result in alternations of ttr, d1, d2, and trgene expression in different tissues of the rare minnow

Wei Li; Jinmiao Zha; Philip A. Spear; Zhaoli Li; Lihua Yang; Zijian Wang

2009

Scholarcy highlights

  • The thyroid hormones triiodothyronine and thyroxine have a wide range of biological effects in physiological processes of vertebrates
  • THs have been implicated as being important regulators of fish in differentiation, growth, metabolism, and salinity adaptation
  • Previous studies indicate that if such processes are disturbed by endocrine disrupting compounds, this could have a dramatic impact on the thyroid endocrine system and reproduction
  • Chinese rare minnow belongs to the subfamily Gobioninae of Cyprinidae. These results further revealed the evolutionary conservation of these genes within the family Cyprinidae
  • Our study indicated that the ttr mRNA levels in the livers were significantly up-regulated after the amitrole exposure and returned to the control levels after the recovery period
  • Plasma thyroid hormone levels At the end of the exposure period, no significant differences in plasma T3 were observed between exposure and control groups of either males or females
  • Previous studies have used deiodinase mRNA as molecular biomarkers for environment contaminants in walleye from the Ottawa River. These results and those of the present study suggest that exposure to amitrole increased the gene expressions of deiodinases which can be used as sensitive biomarkers of thyroid disruption in fish
  • Amitrole exposure could result in alternations of ttr, d1, d2, and trgene expressions in rare minnow in different tissues

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