First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid

The body encloses a complex antioxidant defence grid that relies on endogenous enzymatic and nonenzymatic antioxidants

O.M. Ighodaro; O.A. Akinloye

2017

Scholarcy highlights

  • The body encloses a complex antioxidant defence grid that relies on endogenous enzymatic and nonenzymatic antioxidants
  • The role and effectiveness of the first line defense antioxidants which basically include superoxide dismutase, catalase and glutathione peroxidase is important and indispensable in the entire defense strategy of antioxidants, especially in reference to super oxide anion radical which is perpetually generated in normal body metabolism, through the mitochondrial energy production pathway
  • They are very fast in neutralizing any molecule with the potential of developing into a free radical or any free radical with the ability to induce the production of other radicals
  • Three key enzymes: superoxide dismutase, catalase and glutathione peroxidase are top on the list
  • Peroxynitrate, a powerful oxidant is formed when ⁄O2 reacts with nitric oxide radical in the presence of defense antioxidants which basically include superoxide dismutase, catalase and glutathione peroxidase is important and indispensable in the entire defense strategy of antioxidants, especially in reference to super oxide anion radical which is perpetually generated in normal body metabolism through several processes
  • Chabory et al postulated that individuals with lower Glutathione Peroxidase activity are predisposed to impaired antioxidant protection, which leads to oxidative damage to membrane fatty acid s and functional proteins, and by inference, neurotoxic damage
  • The activities of superoxide dismutase, catalase and glutathione peroxidase constitute a first line antioxidant defence system which plays a key and fundamental role in the total defense mechanisms and strategies in biological systems

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