Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy

The revolution in nanotechnology has brought us new tools in analytical systems and for human applications

Morteza Mahmoudi

2010

Scholarcy highlights

  • The revolution in nanotechnology has brought us new tools in analytical systems and for human applications
  • The Fourier transform infrared spectrum of the synthesized poly-co-fumarate is characteristic of the crystalline phase of polyethylene glycol; asymmetrical C-O-C stretching band, CdC stretching at 1645 cm-1, carbonyl stretching, strong methylene absorption at 2871 cm-1, methylene scissoring and asymmetric bending at 1455 cm-1, and hydroxyl absorption are evident and can be found
  • The 1H NMR spectrum of the synthesized PEGF macromers with a chemical shift at 6.8 ppm clearly indicates that fumarate groups are incorporated into PEG
  • The chemical shifts with peak positions at 3.63, 4.33, 2.7, and 6.8 ppm are due to the protons of PEG main ethylene, methylene groups adjacent to the fumarate groups, the hydroxyl group of PEG, and hydrogens of the fumarate group, respectively
  • The study revealed that by introducing a cross-linking agent to the system, the burst effect was reduced by 21%
  • An MTT assay was used to investigate the biocompatibility of PEGF coated Superparamagnetic iron oxide nanoparticles of various molarities using L929 and K562 cells
  • The C-poly-co-fumarate-magnetic nanoparticles would be a very promising material for simultaneous diagnosis and therapeutic applications

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