TGF-β3-loaded graphene oxide - self-assembling peptide hybrid hydrogels as functional 3D scaffolds for the regeneration of the nucleus pulposus

We developed an injectable graphene oxide - self-assembling peptide FEFKFEFK hybrid hydrogels as potential delivery platform for cells and/or drugs in the nucleus pulposus

Cosimo Ligorio; Marie O'Brien; Nigel W. Hodson; Aleksandr Mironov; Maria Iliut; Aline F. Miller; Aravind Vijayaraghavan; Judith A. Hoyland; Alberto Saiani

2021

Scholarcy highlights

  • Intervertebral disc degeneration is a process that starts in the central nucleus pulposus and leads to inflammation, extracellular matrix degradation, and progressive loss of disc height
  • We explored the possibility of using the graphene oxide present in these hybrid hydrogels as a vehicle for the sequestration and controlled delivery of transforming growth factor beta-3, an anabolic growth factor known to direct NP cell fate and function
  • Our results clearly showed that GO flakes can sequestrate TGF-β3 through strong binding interactions resulting in a slow and prolonged release, with the GF remaining active even when bound to the GO flakes
  • We explored the possibility of using peptide - GO hybrid hydrogels as a vehicle for the sequestration and controlled delivery of transforming growth factor beta-3, an anabolic growth factor known to direct NP cell fate and function

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