Hierarchical self-assembly of magnetic nanoclusters for theranostics: Tunable size, enhanced magnetic resonance imagability, and controlled and targeted drug delivery

We developed superparamagnetic iron oxide nanoparticles that self-assembled into magnetic nanoclusters in aqueous environments as a theranostic nano-system

Dai Hai Nguyen

2016

Scholarcy highlights

  • Nanoparticle-based imaging and therapy are of interest for theranostic nanomedicine
  • The core-shell structure of the magnetic nanoclusters was elucidated based on the condensed superparamagnetic iron oxide core and a Polyethylene glycol shell using electron microscopy and the composition was analyzed by thermogravimetric analysis
  • Our results indicate that nanocluster size could be readily controlled by changing the SPIO/PEG ratio in the assemblies
  • We developed multi-functional SPIO NPs that self-assembled into magnetic nanoclusters in aqueous conditions as a theranostic nano-system
  • We found that nanocluster size could be readily controlled by varying the SPIO/PEG ratio in the assemblies, and demonstrated significant improvement of the functional nanoparticles for theranostic systems; enhanced magnetic resonance, improved cellular uptake, and efficient PTX loading and sustained release at the desired time point
  • Paclitaxel was loaded into the CDs and released at the desired time point

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