The paradoxical role of thioredoxin on oxidative stress and aging

The results generated from our lab and others indicate that: oxidative stress and subsequent changes in signaling pathways could have different pathophysiological impacts at different stages of life; changes in redox-sensitive signaling controlled by levels of oxidative stress and redox state could play more important roles in pathophysiology than accumulation of oxidative damage; changes in oxidative stress and redox state in different cellular compartments could play different roles in pathophysiology during aging, and their combined effects show more impact on aging than changes in either oxidative stress or redox state alone; and the roles of oxidative stress and redox state could have different pathophysiological consequences in different organs/tissues/cells or pathophysiological conditions

Geneva M. Cunningham

2015

Scholarcy highlights

  • The results generated from our lab and others indicate that: oxidative stress and subsequent changes in signaling pathways could have different pathophysiological impacts at different stages of life; changes in redox-sensitive signaling controlled by levels of oxidative stress and redox state could play more important roles in pathophysiology than accumulation of oxidative damage; changes in oxidative stress and redox state in different cellular compartments could play different roles in pathophysiology during aging, and their combined effects show more impact on aging than changes in either oxidative stress or redox state alone; and the roles of oxidative stress and redox state could have different pathophysiological consequences in different organs/tissues/cells or pathophysiological conditions
  • To critically test the role of oxidative stress on aging and investigate changes in redox-sensitive signaling pathways, further study is required

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