Vitamin D and osteoporosis-related fracture

This review provides an overview of current knowledge and suggests a clinical approach to vitamin D status in older adults with, or at risk for, osteoporosis-related fracture

Neil Binkley

2012

Scholarcy highlights

  • The age-related decline in mass and quality of bone and muscle leads to an exponential increased risk for osteoporosis-related fracture with advancing age in older adults
  • As vitamin D inadequacy plausibly causally contributes to these declines, optimization of vitamin D status might reduce the deterioration of bone and muscle function with age
  • This review provides an overview of current knowledge and suggests a clinical approach to vitamin D status in older adults with, or at risk for, osteoporosis-related fracture
  • ► Many patients with osteoporosis and/or fragility fracture have vitamin D deficiency. ► Vitamin D deficiency may be causally related to the development of osteoporosis and sarcopenia. ► Vitamin D deficiency is associated with muscle weakness and increased falls risk. ► The optimal 25(OH)D level in osteoporosis patients is controversial, but 30 ng/mL is suggested

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