Bridging macroscopic and microscopic methods for the measurements of cerebral blood flow

Methods exist to evaluate the cerebral blood flow at both the macroscopic and microscopic spatial scales

I. Kanno

2016

Scholarcy highlights

  • Methods exist to evaluate the cerebral blood flow at both the macroscopic and microscopic spatial scales
  • Each of them determines CBF based on indicator dilution principle or particle fraction principle under the assumption that CBF is steady state during the measurement
  • The microscopic CBF continuously fluctuates in time and space
  • Smoothing out this heterogeneity may lead to underestimation in the macroscopic CBF
  • Applying the defined physiological and/or pharmacological perturbation may provide a good exercise to determine how the specific perturbations interfere the quantitative relationships between the macroscopic and microscopic CBF. Bridging these two-scale methods potentially gives a further indication how the absolute CBF is regulated with respect to a specific type of the cerebrovascular tones or capillary flow velocities in the brain
  • Bridging these two-scale methods potentially gives a further indication how the absolute cerebral blood flow is regulated with respect to a specific type of the cerebrovascular tones or capillary flow velocities in the brain

Need more features? Save interactive summary cards to your Scholarcy Library.