Methods exist to evaluate the cerebral blood flow at both the macroscopic and microscopic spatial scales
2016
Key concepts
Scholarcy highlights
- Methods exist to evaluate the cerebral blood flow at both the macroscopic and microscopic spatial scales
- Each of them determines CBF based on indicator dilution principle or particle fraction principle under the assumption that CBF is steady state during the measurement
- The microscopic CBF continuously fluctuates in time and space
- Smoothing out this heterogeneity may lead to underestimation in the macroscopic CBF
- Applying the defined physiological and/or pharmacological perturbation may provide a good exercise to determine how the specific perturbations interfere the quantitative relationships between the macroscopic and microscopic CBF. Bridging these two-scale methods potentially gives a further indication how the absolute CBF is regulated with respect to a specific type of the cerebrovascular tones or capillary flow velocities in the brain
- Bridging these two-scale methods potentially gives a further indication how the absolute cerebral blood flow is regulated with respect to a specific type of the cerebrovascular tones or capillary flow velocities in the brain
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