Allelic variation at the interleukin-1 receptor antagonist gene is associated with early postmenopausal bone loss at the spine

We examined the relationship between annual rates of change in bone mineral density over 5 years and an 86 bp variable number tandem-repeat polymorphism of the IL-1 receptor antagonist gene gene in 108 early postmenopausal women

R.W Keen

2002

Scholarcy highlights

  • Genetic factors play an important role in determining bone mineral density in later life, with the genetic influence mediated through effects on both peak mass and on age- and menopause-related bone loss
  • Treatment with IL-1ra blocks the bone loss associated with ovariectomy in animals and the IL-1 receptor antagonist gene is a potential candidate gene for the regulation of postmenopausal bone loss
  • We examined the relationship between annual rates of change in BMD over 5 years and an 86 bp variable number tandem-repeat polymorphism of the IL-1RN gene in 108 early postmenopausal women
  • IL-1RN genotype was significantly associated with annual rates of change in spinal bone mass, and this finding remained significant after adjustment for age, weight, and baseline BMD
  • We conclude that allelic variation at the IL-1RN locus is associated with differential rates of early postmenopausal bone loss at the spine
  • Further research will be required to clarify the mechanisms underlying these findings and to determine whether this association translates into a significant long-term effect on bone mineral density and fracture in later life

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