Non-viral and hybrid vectors in human gene therapy: an update

Non-viral DNA vectors have several advantages over viral vectors

Gabriele D Schmidt-Wolf; Ingo G.H Schmidt-Wolf

2003

Scholarcy highlights

  • Non-viral DNA vectors have several advantages over viral vectors
  • The size of the delivered plasmid is limited by the size of the viral capsid, whereas this is not a problem with non-viral vectors
  • The major disadvantage of using non-viral DNA delivery vectors, compared with their viral counterparts, is the low transfection efficiency. This has resulted in low levels of usage in clinical trials
  • The majority of research into non-viral gene therapy has been focused on developing more efficient vectors

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