Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance

This review focuses on hydrophilic swellable matrix tablets as controlled drug delivery systems

Paolo Colombo

2002

Scholarcy highlights

  • The majority of oral drug delivery systems are matrix-based
  • Swellable matrices are monolithic systems prepared by compression of a powdered mixture of a hydrophilic polymer and a drug
  • Swellable matrix DDS must be differentiated from true swelling-controlled delivery systems
  • This review focuses on hydrophilic swellable matrix tablets as controlled DDS
  • Gel-layer behaviour, front movement and release are described to show the dependence of the release kinetics on the swelling behaviour of the system
  • In vivo behaviour of matrix systems is considered

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