T cell responses to Chlamydia trachomatis

This review describes the generation of acquired immunity to C. trachomatis and focuses on how T cells contribute to both protection and immunopathology

W Loomis

2002

Scholarcy highlights

  • Chlamydia trachomatis is the most common cause of bacterial sexually transmitted disease in the United States, as well as the leading cause of preventable blindness worldwide
  • Immunity to C. trachomatis requires a variety of cell types, each employing an array of effector functions
  • Recent work has demonstrated that both CD4+ and CD8+ T lymphocytes play a major role in protective immunity to C. trachomatis, predominantly through their secretion of interferon-γ
  • This review describes the generation of acquired immunity to C. trachomatis and focuses on how T cells contribute to both protection and immunopathology

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