Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver

Since the effects of curcumin on specific glutathione S-transferase isozymes and other glutathione -linked enzymes are incompletely defined, we have examined in the present studies the effect of curcumin on hepatic non-protein sulfhydryls and GSH-linked enzymes in male Sprague-Dawley rats

J Piper

2002

Scholarcy highlights

  • An antioxidant isolated from turmeric, has been shown to attenuate chemical carcinogenesis in rodents
  • Previous studies have shown that curcumin causes an increase in glutathione S-transferase activity in rodent liver which may contribute to its anti-cancer and anti-inflammatory activities
  • Since the effects of curcumin on specific GST isozymes and other glutathione-linked enzymes are incompletely defined, we have examined in the present studies the effect of curcumin on hepatic non-protein sulfhydryls and GSH-linked enzymes in male Sprague-Dawley rats
  • Western-blot analyses of liver cytosols revealed that curcumin caused a dose dependent induction of rGST 8-8, an isozyme which is known to display the highest activity towards 4-HNE, a highly toxic product of lipid peroxidation
  • Our results suggest that induction of enzymes involved in the detoxification of the electrophilic products of lipid peroxidation may contribute to the anti-inflammatory and anti-cancer activities of curcumin

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