Deconstructing a disease: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia.Blood. 1999; 93: 3167-3215
2002
Key concepts
Scholarcy highlights
- Deconstructing a disease: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia.Blood. 1999; 93: 3167-3215
- Et al Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML and PLZF–RARα underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.Blood. 1998; 91: 2634-2642
- Et al SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia.Proc
- Et al SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor.Proc
- Transcriptional silencing is defined by isoform and heterodimer-specific interactions between nuclear hormone receptors and corepressors.Mol
- Et al Signaling by tyrosine kinases negatively regulates the interaction between transcription factors and SMRT corepressor.Mol. Endocrinol
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