Gene Regulation by Thyroid Hormone

Regulation of gene expression by thyroid hormones is mediated via thyroid hormone receptors

Yifei Wu; Ronald J Koenig

2002

Scholarcy highlights

  • Regulation of gene expression by thyroid hormones is mediated via thyroid hormone receptors
  • The binding of ligand triggers a conformational change in the TR that results in the replacement of the corepressor complex by a coactivator complex containing histone acetyltransferase activity, through which the chromatin structure is remodeled, thereby leading to activation of transcription
  • A transcriptional co-repressor that interacts with nuclear hormone receptors.Nature. 1995; 377: 454-457
  • The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors.Nature. 1999; 402: 93-96
  • Et al Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone.Mol
  • Et al Mechanisms that mediate negative regulation of the thyroid-stimulating hormone α gene by the thyroid hormone receptor.J. Biol

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