Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies

We examined whether metabolic impairment induced by 3-nitropropionic acid, an irreversible inhibitor of succinate dehydrogenase, affects the function and viability of microglia in vitro and in vivo

Jae K Ryu; Atsushi Nagai; Jean Kim; Min C Lee; James G McLarnon; Seung U Kim

2003

Scholarcy highlights

  • Metabolic impairment of neurons has been implicated in several neurological disorders, but it is not at present known whether such metabolic impairment has deleterious effects on microglia, the phagocytic cells of the central nervous system
  • We examined whether metabolic impairment induced by 3-nitropropionic acid, an irreversible inhibitor of succinate dehydrogenase, affects the function and viability of microglia in vitro and in vivo
  • reactive oxygen species production induced by 3-NP was inhibited when trolox was coinjected with 3-NP
  • The present results indicate that metabolic impairment in the CNS could involve both activation and cell death of microglia and contribute to pathology in neurodegenerative diseases

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