DNA gyrase inhibitory and antibacterial activity of some flavones(1)

A series of flavones was studied for their DNA-gyrase inhibitory and antibacterial activies

K.A. Ohemeng; C.F. Schwender; K.P. Fu; J.F. Barrett

2002

Scholarcy highlights

  • A series of flavones was studied for their DNA-gyrase inhibitory and antibacterial activies
  • A series of flavones was studied for their DNA-gyrase inhibitory and antibacterial activities, This led to the identification of compounds with potent Escherichia coli DNA-gyrase inhibitory activity, and modest antimicrobial activity
  • The most active compound, ellagic acid has an IC50 = 3.3 μ/ml, which is comparable to some of the currently marketed 4-quinolone antibacterials

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