Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres

The goal of this work is to develop poly(lactide-co-glycolide) nanospheres designed to deliver proteins for extended periods of time

M.D Blanco

2002

Key concepts

Scholarcy highlights

  • The goal of this work is to develop poly(lactide-co-glycolide) nanospheres designed to deliver proteins for extended periods of time
  • A study was performed to evaluate how the solvent elimination procedure, the copolymer type and the surfactant Poloxamer 188 affected the properties of the nanoparticles
  • The protein loading efficiency varied from 40 to 90%, reaching the maximum values for the formulations made of PLGA with free carboxyls
  • The release rate was significantly reduced for the copolymer with terminal free carboxyls but was enhanced by the incorporation of Poloxamer 188 in the nanoparticles
  • These nanoparticles can be proposed as new controlled release protein delivery systems

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