The role of hepatocytes and oval cells in liver regeneration and repopulation

We review some aspects of the regulation of hepatocyte proliferation as well as the interrelationships between hepatocytes and oval cells in different liver growth processes

Nelson Fausto; Jean S. Campbell

2002

Scholarcy highlights

  • The liver has the unique capacity to regulate its growth and mass. It grows rapidly after resection of more than 50% of its mass. This growth process, as well as that following acute chemical injury is known as liver regeneration, growth takes place by compensatory hyperplasia rather than true regeneration
  • We review some aspects of the regulation of hepatocyte proliferation as well as the interrelationships between hepatocytes and oval cells in different liver growth processes
  • Bone marrow stem cells can generate oval cells and hepatocytes, transdifferentiation is very rare and inefficient

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