Cloning of zebrafish T-box genes tbx15 and tbx18 and their expression during embryonic development

We find both similarities and differences in expression between the orthologs of tbx18

Gerrit Begemann; Yann Gibert; Axel Meyer; Phillip W. Ingham

2002

Scholarcy highlights

  • T-box genes encode a large family of transcription factors, whose importance in development is emphasised by the identification of several mutations in tbx genes linked to human hereditary syndromes
  • To identify tbx genes that are expressed during limb and head development, we cloned two novel zebrafish T-box genes which we call tbx15 and tbx18
  • Human Tbx15 shows linkage with acromegaloid facial appearance, a dominant human syndrome that affects many of the tissues that express Tbx15 in the mouse
  • Expression of zebrafish tbx15 in the cranial paraxial mesoderm, the head musculature and the somites are novel features not reported in the mouse
  • Expression surrounding the eyes, in the branchial region and in forelimbs are reminiscent of the mouse expression pattern. We find both similarities and differences in expression between the orthologs of tbx18
  • Sequencing and phylogenetic analyses identified two clones as homologues of tbx15 and tbx18 in humans and mouse

Need more features? Save interactive summary cards to your Scholarcy Library.