The results show a low association of PZA resistance and pncA gene mutations in a selected patient group from an highly endemic area
2002
Key concepts
- infrared spectra
- Mycobacterium bovis
- purified protein derivative
- ELISA
- enzootic pneumonia
- chemical analysis
- nuclear magnetic resonance
- M. tuberculosis
- M. bovis
- humic acid
- thin layer chromatography
- minimum inhibitory concentration
- bovine tuberculosis
- multidrug resistant
- Polyethylene oxide
- sodium alginate
- bovine serum albumin
- pyrazinoic acid
- Escherichia coli
Scholarcy highlights
- The sensitivity and specificity of the assay were investigated using sera of cattle from tuberculosis-free herds and from tuberculosis-infected herds
- No correlation was found between di-O-acyl trehalose-ELISA and the skin test, nor between DAT-ELISA and interferon-γ with bovine purified protein derivative
- The antibody titres were not related to cell-mediated immunity
- The objective of the study was to investigate the correlation between PZA susceptibility and mutations in pncA gene in M. tuberculosis isolates from individuals living in a highly endemic area
- All PZA resistant isolates had no mutation in the gene coding ribosomal protein S1, which has recently been proposed as alternate target for pyrazinoic acid
- The results showed that the hydrophilic modification of UF membrane contributed to the fouling control in bovine serum albumin and Escherichia coli bacteria filtration
- The low sensitivity of ELISA might be attributed to a reciprocal relationship between B-cell proliferation and T-cell protective immunity
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